The tissues, structures and organs of our body, are constituted by numerous cells. These cells grow constantly in an orderly and controlled manner. When this control is lost, the cells grow rapidly, excessively and chaotically - resulting in cancer. Although more in number, they do not do their desired function. On the contrary, they cause:
- Mechanical compression of vital neighbouring structures, nerves and vessels
- Obstruction of tubes and pathways
- Bleeding and perforation
- Fall in immune status, causing infection
These cells get transported to nearby lymphnodes, by lymphatics, and to distant organs and bones, by blood. This is called metastasis.
So, the symptoms and signs of cancer depends on its primary site (origin) or its areas of metastasis (spread). Sometimes (8%), certain systemic effects of cancer can be found, away from the site of its origin or spread - due to hormonal and immunological effects. This is called paraneoplastic syndrome.
Based on the symptoms of a person, detection of cancer is done by Oncologists (cancer specialists), through physical examination, blood tests (includes tumor markers), X-rays, scans and endoscopies. However, the diagnosis is always through (there are exceptions although) pathological examination of the material obtained through aspiration or biopsy from the tissue or organ, suspected to have cancer. The next step in the management of cancer is to know the extent of the disease - The staging. This again, is by physical examination of the patient by the oncologist, scopies if necessary, and by radiological examination.
Treatment of cancer depends on
- Site of cancer (breast, lung, blood, etc.,)
- It's type (Carcinoma, Lymphoma, etc.,)
- Age of the patient
- Stage of cancer
- Grade
- General condition of the patient and co-morbidities
Treatment modalities for cancer are:
- Medicine or chemicals
- Radiation
- Surgery
Depending on the site, type, stage and grade of the cancer diagnosed, one or more of the above modalities are used to treat - the aim being cure (curative or adjuvant) or alleviation (palliative).
With the advances made in cancer treatments recently (minimal access and conservation surgeries, cyber knife radiation, intensity modulated radiotherapy, targeted medical therapies, antiangiogenic therapies and monoclonal antibody therapy) curing cancer is possible in early stages and has become easier.